Death of A Cell: Test Your Knowledge

  1. Which were often of the following factors is not a mechanism that will induce apoptosis in a cell?
    1. death receptor
    2. free radicals
    3. viral infection
    4. AKT formation
    5. Ionizing radiation

  2. T. cells can initiate apoptosis in order to prevent damaged cells from becoming cancerous and in. (True or False) (6 points)

  3. The enzyme granzyme works with the T-cells to preventing apoptosis. (True or False) (6 points)

  4. Intrinsic signals initiate apoptosis via the involvement of the organelles in the cells called the_________________.(6 points)

  5. Which of the following does not block or inhibit apoptosis? (6 points)
    1. FLICE protein
    2. Granzyme enzyme
    3. Bcl-2
    4. Cytokine response modifier A
  6. Some genes are known to be pro-apoptosis genes and some are known to be anti-apoptosis genes. From the following list put the letter P in the blanks in front of the pro-apoptosis gene and put an A in front of the anti-apoptosis gene. (21 points)

  7. Oncogenes are genes that cause the formation of cancers and tumors. (True or False) (6 points)

  8. PCR and gel electrophoresis can be used to identify genes, but are not specific enough to distinguish between normal tissue and cancer tissue. (True or False) (6 points)

  9. The HPV virus and the EBV virus will try to inactivate the ___________ gene so that apoptosis can not occur. (6 points)

  10. The inhibition of the apoptosis pathway happen in which of the following diseases. (6 points)
    1. Leukemia
    2. Melanoma
    3. Lung cancer
    4. Only A and C
    5. All the above
  11. List the three phases that the "decision" to initiate apoptosis come from. (9 points)

  12. Cell death by necrosis and apoptosis are the same since in each instance the cell shrinks and fragments and the fragments are phagocytosed. (True or False) (6 points)

  13. What role does caspases perform in apoptosis? (6 points)

  14. Name four methods of laboratory assays for apoptosis. (12 points)